diff --git a/.changeset/fruity-groups-brush.md b/.changeset/fruity-groups-brush.md
new file mode 100644
index 00000000000..74ee1e9d819
--- /dev/null
+++ b/.changeset/fruity-groups-brush.md
@@ -0,0 +1,5 @@
+---
+'@primer/react': minor
+---
+
+Added callback prop onActiveDescendantChanged to FilteredActionList
diff --git a/packages/react/src/FilteredActionList/FilteredActionList.tsx b/packages/react/src/FilteredActionList/FilteredActionList.tsx
index 6589e9eb983..fa5164ecc57 100644
--- a/packages/react/src/FilteredActionList/FilteredActionList.tsx
+++ b/packages/react/src/FilteredActionList/FilteredActionList.tsx
@@ -60,6 +60,18 @@ export interface FilteredActionListProps extends Partial<Omit<GroupedListProps,
    *  @default 'wrap'
    */
   focusOutBehavior?: 'stop' | 'wrap'
+  /**
+   * Callback function that is called when the active descendant changes.
+   *
+   * @param newActiveDescendant - The new active descendant element.
+   * @param previousActiveDescendant - The previous active descendant element.
+   * @param directlyActivated - Whether the active descendant was directly activated (e.g., by a keyboard event).
+   */
+  onActiveDescendantChanged?: (
+    newActiveDescendant: HTMLElement | undefined,
+    previousActiveDescendant: HTMLElement | undefined,
+    directlyActivated: boolean,
+  ) => void
   /**
    * Private API for use internally only. Adds the ability to switch between
    * `active-descendant` and roving tabindex.
@@ -115,6 +127,7 @@ export function FilteredActionList({
   actionListProps,
   focusOutBehavior = 'wrap',
   _PrivateFocusManagement = 'active-descendant',
+  onActiveDescendantChanged,
   disableSelectOnHover = false,
   setInitialFocus = false,
   ...listProps
@@ -239,16 +252,17 @@ export function FilteredActionList({
           activeDescendantFocus: inputRef,
           onActiveDescendantChanged: (current, previous, directlyActivated) => {
             activeDescendantRef.current = current
-
             if (current && scrollContainerRef.current && directlyActivated) {
               scrollIntoView(current, scrollContainerRef.current, menuScrollMargins)
             }
+
+            onActiveDescendantChanged?.(current, previous, directlyActivated)
           },
           focusInStrategy: setInitialFocus ? 'initial' : 'previous',
           ignoreHoverEvents: disableSelectOnHover,
         }
       : undefined,
-    [listContainerElement, usingRovingTabindex],
+    [listContainerElement, usingRovingTabindex, onActiveDescendantChanged],
   )
 
   useEffect(() => {
diff --git a/packages/react/src/SelectPanel/SelectPanel.docs.json b/packages/react/src/SelectPanel/SelectPanel.docs.json
index 370af70ee9c..8980b64d1d6 100644
--- a/packages/react/src/SelectPanel/SelectPanel.docs.json
+++ b/packages/react/src/SelectPanel/SelectPanel.docs.json
@@ -222,9 +222,15 @@
     },  
     {
       "name": "focusOutBehavior",
-       "type": "'start' | 'wrap'",
+      "type": "'start' | 'wrap'",
       "defaultValue": "'wrap'",
       "description": "Determines how keyboard focus behaves when navigating beyond the first or last item in the list."
+    },
+    {
+      "name": "onActiveDescendantChanged",
+      "type": "(newActiveDescendant: HTMLElement | undefined, previousActiveDescendant: HTMLElement | undefined, directlyActivated: boolean) => void | undefined",
+      "defaultValue": "undefined",
+      "description": "Callback function that is called when the active descendant changes."
     }
   ],
   "subcomponents": []
diff --git a/packages/react/src/SelectPanel/SelectPanel.examples.stories.tsx b/packages/react/src/SelectPanel/SelectPanel.examples.stories.tsx
index 64f6c723f75..864d6e02b62 100644
--- a/packages/react/src/SelectPanel/SelectPanel.examples.stories.tsx
+++ b/packages/react/src/SelectPanel/SelectPanel.examples.stories.tsx
@@ -1,4 +1,4 @@
-import React, {useState, useMemo, useRef, useEffect} from 'react'
+import React, {useState, useMemo, useRef, useEffect, useCallback} from 'react'
 import type {Meta} from '@storybook/react-vite'
 import {Button} from '../Button'
 import type {ItemInput} from '../FilteredActionList'
@@ -627,54 +627,14 @@ export const Virtualized = () => {
     count: filteredItems.length,
     getScrollElement: () => scrollContainer ?? null,
     estimateSize: () => DEFAULT_VIRTUAL_ITEM_HEIGHT,
-    overscan: 10,
+    overscan: 5,
     enabled: renderSubset,
+    getItemKey: index => filteredItems[index].id,
     measureElement: el => {
       return (el as HTMLElement).scrollHeight
     },
   })
 
-  const virtualizedContainerStyle = useMemo(
-    () =>
-      renderSubset
-        ? {
-            height: virtualizer.getTotalSize(),
-            width: '100%',
-            position: 'relative' as const,
-          }
-        : undefined,
-    [renderSubset, virtualizer],
-  )
-
-  const virtualizedItems = useMemo(
-    () =>
-      renderSubset
-        ? virtualizer.getVirtualItems().map((virtualItem: VirtualItem) => {
-            const item = filteredItems[virtualItem.index]
-
-            return {
-              ...item,
-              key: virtualItem.index,
-              'data-index': virtualItem.index,
-              ref: (node: Element | null) => {
-                if (node && node.getAttribute('data-index')) {
-                  virtualizer.measureElement(node)
-                }
-              },
-              style: {
-                position: 'absolute',
-                top: 0,
-                left: 0,
-                width: '100%',
-                height: `${virtualItem.size}px`,
-                transform: `translateY(${virtualItem.start}px)`,
-              },
-            }
-          })
-        : filteredItems,
-    [renderSubset, virtualizer, filteredItems],
-  )
-
   return (
     <form>
       <FormControl>
@@ -709,7 +669,32 @@ export const Virtualized = () => {
           )}
           open={open}
           onOpenChange={onOpenChange}
-          items={virtualizedItems}
+          items={
+            renderSubset
+              ? virtualizer.getVirtualItems().map((virtualItem: VirtualItem) => {
+                  const item = filteredItems[virtualItem.index]
+
+                  return {
+                    ...item,
+                    key: item.id,
+                    'data-index': virtualItem.index,
+                    ref: (node: Element | null) => {
+                      if (node && node.getAttribute('data-index')) {
+                        virtualizer.measureElement(node)
+                      }
+                    },
+                    style: {
+                      position: 'absolute',
+                      top: 0,
+                      left: 0,
+                      width: '100%',
+                      height: `${virtualItem.size}px`,
+                      transform: `translateY(${virtualItem.start}px)`,
+                    },
+                  }
+                })
+              : filteredItems
+          }
           selected={selected}
           onSelectedChange={setSelected}
           onFilterChange={setFilter}
@@ -719,10 +704,27 @@ export const Virtualized = () => {
           overlayProps={{
             id: 'select-labels-panel-dialog',
           }}
+          onActiveDescendantChanged={useCallback(
+            (newActivedescendant: HTMLElement | undefined) => {
+              const index = newActivedescendant?.getAttribute('data-index')
+              const range = virtualizer.range
+              if (newActivedescendant === undefined) return
+              if (index && range && (Number(index) < range.startIndex || Number(index) >= range.endIndex)) {
+                virtualizer.scrollToIndex(Number(newActivedescendant.getAttribute('data-index')), {align: 'auto'})
+              }
+            },
+            [virtualizer],
+          )}
           focusOutBehavior="stop"
           scrollContainerRef={node => setScrollContainer(node)}
           actionListProps={{
-            style: virtualizedContainerStyle,
+            style: renderSubset
+              ? {
+                  height: virtualizer.getTotalSize(),
+                  width: '100%',
+                  position: 'relative' as const,
+                }
+              : undefined,
           }}
         />
       </FormControl>
diff --git a/packages/react/src/SelectPanel/SelectPanel.test.tsx b/packages/react/src/SelectPanel/SelectPanel.test.tsx
index 47ee19a457d..57c2b8cbb98 100644
--- a/packages/react/src/SelectPanel/SelectPanel.test.tsx
+++ b/packages/react/src/SelectPanel/SelectPanel.test.tsx
@@ -85,6 +85,19 @@ for (const usingRemoveActiveDescendant of [false, true]) {
       expect(trigger).toHaveAttribute('aria-expanded', 'false')
     })
 
+    it('should call onActiveDescendantChanged when using keyboard while focusing on an item', async () => {
+      const user = userEvent.setup()
+      // jest function
+      const onActiveDescendantChanged = vi.fn()
+
+      render(<BasicSelectPanel onActiveDescendantChanged={onActiveDescendantChanged} />)
+
+      await user.click(screen.getByText('Select items'))
+
+      await user.type(document.activeElement!, '{ArrowDown}')
+      expect(onActiveDescendantChanged).toHaveBeenCalled()
+    })
+
     it('should open the select panel when activating the trigger', async () => {
       const user = userEvent.setup()